| Laboratory: | Hematology |
| Test Name: |
ADAMTS13 ACTIVITY AND INHIBITOR PROFILE - (P)
Test Code:
ADAM
|
| Clinical Information: |
Test performed at: University of Iowa
PRIOR APPROVAL required, except Nephrologists and Hematologists. Must collect prior to initiating plasma exchange. Test Indications: It’s essential for the diagnosis of congenital or acquired TTP (thrombotic thrombocytopenic purpura). Less than 10% ADAMTS-13 activity is highly indicative of TTP in an appropriate clinical setting. TTP is a medical emergency (untreated has nearly 100% mortality and treated in a timely manner has a >90% survival rate), which requires prompt diagnosis, and costly plasma exchange for the patient. |
| Collection Devices: |
Preferred Device:
|
| Specimen Required: |
Whole Blood: 4.4 mL
Pediatric Whole Blood: 3.6 mL
Sample must be sent to the lab immediately. Double spin of plasma required in three (3) separate aliquots. Transfer top two thirds of plasma from collection tube to a new plastic tube. Re-centrifuge and then remove the top two thirds of plasma and place into a new plastic tube. Cap and freeze immediately in three (3) separate aliquots. For best results, centrifuged and separated within 60 minutes of collection. |
| Referral: |
Plasma: 2.0 mL
Pediatric Plasma: 1.0 mL
Refer frozen plasma to HSC Central Services on a STAT basis. Referred Out Location: MORL, Iowa City, IA Must be shipped and remain frozen with dry ice. Freeze plasma immediately at -20°C (-80°C preferred). One (1) aliquot is retained at HSC Central Services where volume permits. |
| Requisition: | |
| Reference Values: |
See report.
|
| Availability: |
Daily
Test must be approved by the Hematopathologist on service, except Nephrologists and Hematologists.
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| See Also: | |
| More Information: |
As per MORL:
Delivery: Monday to Friday (NO WEEKEND DELIVERIES) Thawed OR unlabeled samples will be REJECTED for testing. Specimens cannot be shipped on Friday, holidays, weekends. Minimum plasma volume: 0.5 mL Inhibitor studies will be reflexed automatically when Activity is <25%. Ordering physician to complete Coagulation Patient Information Sheet to accompany the test sample: |