Laboratory: Clinical Immunology
Test Name:
IGG IMMUNOGLOBULIN - (S)
Test Code: IGG
Clinical Information:
Alternate Name(s): Gamma-Globulins Quantitative, IgG (Immunoglobulin G)

Aid in diagnosis or monitoring of monoclonal gammopathies and immune deficiencies.
 
In normal adults, IgG constitutes approximately 75% of the total serum immunoglobulin. Within the IgG class, the usual order of concentration of the 4 subclasses is IgG1>IgG2>IgG3>IgG4, but the actual concentration of each may vary markedly between individuals. The four IgG subclasses show considerable differences in their properties, including ability to fix complement, to bind to macrophages and to pass through the placenta. Abnormal levels of one or more subclass may be associated with certain conditions, including anaphylaxis, autoimmune- and gut diseases as well as hypo- and hyper-gammaglobulinemia.
 
Values should be used in conjunction with other laboratory and clinical findings.
 
Collection Devices:
Specimen Required:
Serum: 1.0 mL
Pediatric Serum: 0.5 mL

Refrigerated: 14 days
Frozen: 30 days
Referral:
Serum: 1.0 mL
Pediatric Serum: 0.5 mL

Shipping & Storage: Separate serum and ship refrigerated, or frozen if greater than 7 days from time of collection.

Testing Laboratory (MB): Health Sciences Centre Immunology Laboratory

The volumes listed are sufficient to perform quantitation of IgG, IgA, IgM
Requisition:
Reference Values:
           Age (yrs)                    g/L
0 - 2 2.42 – 11.08
3 – 4 4.85 – 11.60
5 – 9 5.14 – 16.72
10 – 14 5.81 – 16.52
15 – 18 4.79 – 14.33
Adult 19+ 6.10 – 16.16
 
Pediatric reference values adopted from Garcia-Prat M, Vila-Pijoan G, Martos Gutierrez S, et al. Age-specific pediatric reference ranges for immunoglobulins and complement proteins on the Optilite™ automated turbidimetric analyzer. J Clin Lab Anal. 2018;32:e22420. https://doi.org/10.1002/jcla.22420.
 
Adult reference values adopted from Binding Site, Optilite IgG Kit, INS004.OPT,    ver 19th January 2015

Method of Analysis: Turbidimetry – Binding Site Optilite
Availability:
Weekdays
See Also:
More Information:
Reportable Range: 0.17 – 140.00 g/L
 
Undetected antigen excess is a rare event but cannot be excluded. If these results do not agree with other clinical or laboratory findings, or if the sample is from a patient that has previously demonstrated antigen excess, the result must be checked by retesting at a higher sample dilution. Results should always be interpreted in conjunction with other laboratory tests and clinical evidence; any anomalies should be discussed with the laboratory.