View Test

Laboratory:

Clinical Biochemistry (BIOCHEMICAL GENETICS)

Test Name:

HOMOCYSTEINE, TOTAL by LC-MS/MS - (P)

Test Code: HCQ

Clinical Information:

Test Indications: Elevations in plasma homocysteine are commonly found as a result of vitamin deficiencies (pyridoxal, folate, riboflavin, B12), polymorphisms of enzymes of methionine metabolism, and renal disease.

Severely elevated concentrations of total homocysteine are found in subjects with homocystinuria, a rare genetic disorder of the enzymes involved in the metabolism of homocysteine

Collection Devices:

Preferred Device:	1 - EDTA 4 mL NO GEL Tube(s) - Full Tube Collection EDTA 4 mL NO GEL Tube(s) - Full Tube Collection Manufacturer: Becton Dickinson & Company Catalogue #: 367861 - OR Li Heparin Plasma Separator Tube(s) - Full Tube Collection
Alternate Device:	1 - Microtainer(s) - Li Heparin PST (0.6mL) to fill line Microtainer(s) - Li Heparin PST (0.6mL) to fill line Manufacturer: Becton Dickinson & Company Catalogue #: 365987

Specimen Required:

Plasma: 1.0 mL

Pediatric Plasma: 0.5 mL

Collection Information: Immediately place specimen on wet ice and send to the lab
Special Processing: It is important to centrifuge blood samples immediately (<20 min) after collection to separate the plasma from the blood cells.
If immediate centrifugation is not possible, collect on ice and centrifuged within an hour. Aliquot immediately.
Specimen Stability:
Ambient: N/A
Refrigerated: 1 month (separated from cells)
Frozen: 6 months

Referral:

Shipping & Storage: Store and send refrigerated or frozen. Specimen not received on ice will be rejected.
Testing Laboratory (MB):
HSC (Health Sciences Centre) – Biochemistry MS5
Biochemical Genetics Lab / Metabolic Lab
Inquiries: 204-787-4530

Requisition:

_SH Biochemical Genetics Laboratory Requisition (R250-10-69)

Reference Values:

Reference Intervals: 4.5 - 13 μmol/L
Method of Analysis: Liquid Chromatography Tandem Mass Spectrometry

Availability:

Within 1 Week