Laboratory: Clinical Biochemistry
Test Name:
VEGF-D Quantitation - (S)
Test Code: MISC
Clinical Information:
This is not the same as the VEGF test. That test requires Immunology/Hematology approval for test referral.
This test must be approved by a Clinical Chemist prior to sendout.
Click here for the Approval for Test Referral Biochemistry form (F260-11-02)

Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily affects women of childbearing age. American Thoracic Society Clinical Practice Guidelines recommend vascular endothelial growth factor D (VEGF-D) testing to establish the diagnosis of LAM before proceeding to diagnostic lung biopsy in patients whose CTscan shows cystic abnormalities characteristic of LAM. The guidelines recommend a VEGF-D diagnostic threshold of 800 pg/mL.
Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. American Journal of Respiratory and Critical Care Medicine 2016, 194(6): 748-761
Collection Devices:
Specimen Required:
Serum: 3.0 mL

Centrifuge within two hours of collection. Store and ship frozen in a polypropylene tube. Do not thaw.
Serum: 3.0 mL

Store and ship frozen in a polypropylene tube Do not thaw.
Reference Values:
A descriptive report will be sent
Within 4 Weeks
Available to respirologists for investigation of possible LAM in the setting of an appropriate CT scan.
See Also:
More Information:
Send specimen to HSC Clinical Biochemistry Lab MS551. Specimen will be forwarded to Cincinnati Children's Hospital Translational Trials Development and Support Lab (TTDSL) for testing.