| Laboratory: | Clinical Biochemistry |
| Test Name: |
VEGF-D Quantitation - (S)
Test Code:
MISC
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| Clinical Information: |
This is not the same as the VEGF test. That test requires Immunology/Hematology approval for test referral.
This test must be approved by a Clinical Chemist prior to sendout. Click here for the Approval for Test Referral Biochemistry form (F260-11-02) Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily affects women of childbearing age. American Thoracic Society Clinical Practice Guidelines recommend vascular endothelial growth factor D (VEGF-D) testing to establish the diagnosis of LAM before proceeding to diagnostic lung biopsy in patients whose CTscan shows cystic abnormalities characteristic of LAM. The guidelines recommend a VEGF-D diagnostic threshold of 800 pg/mL. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. American Journal of Respiratory and Critical Care Medicine 2016, 194(6): 748-761 |
| Collection Devices: |
Preferred Device:
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| Specimen Required: |
Serum: 3.0 mL
Centrifuge within two hours of collection. Store and ship frozen in a polypropylene tube. Do not thaw. |
| Referral: |
Serum: 3.0 mL
Store and ship frozen in a polypropylene tube Do not thaw.
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| Requisition: | |
| Reference Values: |
A descriptive report will be sent
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| Availability: |
Within 4 Weeks
Available to respirologists for investigation of possible LAM in the setting of an appropriate CT scan.
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| See Also: | |
| More Information: |
Send specimen to HSC Clinical Biochemistry Lab MS551. Specimen will be forwarded to Cincinnati Children's Hospital Translational Trials Development and Support Lab (TTDSL) for testing.
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