| Laboratory: | Genomics (MOLECULAR DIAGNOSTICS) |
| Test Name: |
MITOCHONDRIAL RESPIRATORY CHAIN ENZYME ANALYSIS - SKELETAL MUSCLE
Test Code:
MD
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| Clinical Information: |
Description: Mitochondrial respiratory chain enzyme assesses potential enzyme deficiencies mitochondrial respiratory chain complex I through IV.
This enzyme analysis is performed on muscle and the following enzymes are analyzed: • Ferricyanide: NADH dehydrogenase I • NADH: Cytochrome c reductase I-III • Succinate dehydrogenase II • Succinate: Cytochrome c reductase II-III • Cytochrome c oxidase IV • Citrate synthase Values are normalized to citrate synthase if necessary.
Test Approval Requirements: Contact Lab Genetic Counsellor at GenomicsLabGC@sharedhealthmb.ca or ph:204-787-4033 with any questions. Requests will be reviewed and approved by either a Molecular Geneticist or a committee of physicians with expertise in genetic and genomic conditions |
| Collection Devices: |
Appropriate container for flash freezing of tissue sample, as per current Pathology protocols
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| Specimen Required: |
Specimen Type: tissue Collection Information: Minimum of 150 mg skeletal muscle (200 mg preferred) should be flash frozen in liquid nitrogen at collection with no media added. Store at -80°C until shipping time. Specimen Stability: Must be kept frozen and on dry ice |
| Referral: |
Shipping & Storage: Ship by overnight courier on 3-5 lbs. of dry ice
Other comments: An interpretive report from the referral laboratory will be forwarded to the ordering physician. |
| Requisition: | |
| Reference Values: | |
| Availability: |
By Prior Arrangement Only
Completed_SH Molecular Diagnostic Laboratory Out of Centre Genetic Test Requisition (R250-10-103) must be faxed to Laboratory Genetic Counselors at 204-787-2563 for review. Once approved, Laboratory team will transfer the appropriate sample from Pathology to Genomics, and process send out
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| More Information: |