Laboratory: Clinical Biochemistry
Test Name:
Test Code: PGN
Clinical Information:
Test performed at:  Health Sciences Centre, St. Boniface Hospital and Westman Lab
Progesterone is a steroid hormone produced by the corpus luteum of the ovary and during pregnancy by the placenta. Plasma progesterone concentration correlates with the development and regression of the corpus luteum. It is barely detectable in the follicular phase of the menstrual cycle, starts to increase at ovulation and continues to increase during the luteal phase. It functions to prepare the uterine mucosa for potential implantation of a fertilized ovum. Its concentration drops rapidly at the end of the cycle if implantation has not occurred. During pregnancy it inhibits contraction of the myometrium to help support the pregnancy.
Progesterone determination is used in the investigation of fertility to detect if ovulation has occurred and for assessment of the adequacy of the luteal phase.
Patient Preparation Instructions: Multivitamins (45–125 µg biotin) or biotin-only supplements up to 1 mg per day do not interfere with this test. Samples should not be taken from patients receiving therapy with high biotin doses (i.e. >5 mg/day) until at least 8 hours after the last dose.
Collection Devices:
Specimen Required:

Plasma: 2.0 mL

5 days refrigerated, 6 months frozen
Serum: 2.0 mL

Samples must be transferred to an aliquot tube and stored frozen if analysis will not be complete within 48 hours (#110-10-05 Serum / Plasma Separation Procedure & Transport)
Reference Values:
Female:   Male:  
Prepubertal: < 2 nmol/L 0 - 12 y: < 2 nmol/L
Follicular: < 4 ≥ 13 y: < 3
Luteal: 6-80    
(nmol/L x 31.4 = ng/dL)
See Also:
More Information:
Li Heparin Plasma Separator Tube(s) - Full Tube Collection
Manufacturer: BD (Becton Dickinson)

Catalogue #: 367962