Laboratory: Clinical Biochemistry  (AUTOMATED)
Test Name:
CREATININE - (P)
Test Code: CR
Clinical Information:
Chronic kidney disease carries a substantial risk for cardiovascular morbidity and mortality. Chronic kidney disease is defined as kidney damage or glomerular filtration rate (GFR) less than 60 mL/minute per 1.73 m2 for three months or more. 


See additional information on eGFR and referral pathways at Manitoba Renal Program website.

 
The assay of plasma creatinine is the most commonly used test to assess renal function. It is a breakdown product of creatine phosphate in muscle, and is produced at a fairly constant rate by the body. It is freely filtered by the glomeruli and is not reabsorbed by the tubules. A small but significant amount is also actively secreted. 


In addition to the diagnosis and treatment of renal disease and monitoring of renal dialysis, creatinine measurements are used for the calculation of the fractional excretion of other urine analytes (e.g. albumin).


Test Indications:
eGFR (CKD-EPI equation) will be reported automatically with all creatinine results for outpatients (excludes Emergency) or referred-in specimens. 

·        Note: for hospital inpatients or Emergency patients, eGFR will not be reported unless specifically requested by ordering test code EGFR.
Collection Devices:
Pediatric samples should be collected in LiHep PST microtainer (0.6 mL) 
Specimen Required:


Plasma: 2.0 mL
Pediatric Plasma: 0.2 mL

Specimen Stability:

Ambient: 7 days 

Refrigerated: 7 days 

Frozen: 3 months at -20oC 
Referral:
Serum: 2.0 mL

Adult Volume: 2.0 mL serum or plasma aliquoted

Shipping & Storage: Samples must be transferred to an aliquot tube and stored/shipped

·        Refrigerated if off-site testing to be performed within 48 hours of collection

·        Frozen if testing to be performed after 48 hours

See #110-10-05 Serum / Plasma Separation Procedure & Transport
Requisition:
Reference Values:
Effective March 11, 2024 
 
AgeMaleFemale
0 - 14 d: 

35 - 86 µmol/L

15 d - 1 y: 

15 - 38 µmol/L

2 - 4 y: 

24 - 43 µmol/L

5 - 11 y:

33 - 59 µmol/L

12 - 14 y:

45 - 77 µmol/L

15 - 18 y:

60 -100 µmol/L

48 - 79 µmol/L

≥ 19 y:

59 - 104  µmol/L

45 - 84 µmol/L

Method of Analysis: Enzymatic colorimetric
Availability:
Stat or Routine
See Also:
More Information: