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Laboratory:

Genomics (MOLECULAR DIAGNOSTICS)

Test Name:

BRCA1 & BRCA2 GENE ANALYSIS - (B)

Test Code: MD

Clinical Information:

Description: BRCA1 and BRCA2 gene sequence analysis, including the entire coding region and flanking intronic DNA (+/- 10 bp) is performed. Testing is designed to guide therapy management in patients diagnosed with cancer who may have a germline variant in the genes analyzed.

Ordering clinician should include the clinical diagnosis and possible treatment date.

Note, non-coding regions such as promoters, deep intronic regions, and untranslated regions are not usually examined by this analysis.

Please specify ethnicity on the requisition.

Ordering restricted to: Medical Genetics and selected Oncologists

Collection Devices:

Preferred Device:

2 - EDTA 4 mL NO GEL Tube(s) - Full Tube Collection

EDTA 4 mL NO GEL Tube(s) - Full Tube Collection
Manufacturer: Becton Dickinson & Company

Catalogue #: 367861

Alternate Device:

2 - Microtainer(s) - EDTA, NO GEL (0.5 mL) to fill line

Microtainer(s) - EDTA, NO GEL (0.5 mL) to fill line
Manufacturer: Becton Dickinson & Company

Catalogue #: 363706

- Microtainer quantity: 2-6

Note that extracted DNA samples can only be accepted from accredited laboratories. Contact Lab Genetic Counsellor at GenomicsLabGC@sharedhealthmb.ca or ph:204-787-4033 with any questions.

Specimen Required:

Whole Blood: 8.0 mL

Pediatric Whole Blood: 1.0 mL

Pediatric: 1.0-3.0 mL
Special Processing: Do NOT centrifuge. Specimen is forwarded to Health Sciences Centre MS551 for analysis.
Specimen Stability:
Ambient: Preferred - store and ship specimens at room temperature
Refrigerated: Accepted
Frozen: Accepted - must remain frozen
Other comments: Specimens sent for Molecular tests are not to be used for other tests (i.e. CBC).

Referral:

Requisition:

_SH Hereditary Cancer Molecular Requisition (R250-10-10)

Reference Values:

Reference Intervals: An interpretive report will be sent

Availability:

Within 6 Weeks