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Laboratory:

Genomics (MOLECULAR DIAGNOSTICS)

Test Name:

BRCA1 & BRCA2 GENE ANALYSIS - (B)

Test Code: MD

Clinical Information:

Test Indications: BRCA1 and BRCA2 gene sequence analysis including the entire coding region and flanking intronic DNA (+/- 10 bp) is performed. Testing is designed to guide therapy management in patients diagnosed with cancer who may have a germline variant in the genes analyze.

Ordering clinician should include the clinical diagnosis and possible treatment date.

Note, non-coding regions such as promoters, deep intronic regions, and untranslated regions are not usually examined by this analysis.

Ordering restricted to: Medical Genetics and selected Oncologists

Collection Devices:

Preferred Device:

2 - EDTA 4 mL NO GEL Tube(s) - Full Tube Collection

EDTA 4 mL NO GEL Tube(s) - Full Tube Collection
Manufacturer: Becton Dickinson & Company

Catalogue #: 367861

Specimen Required:

Whole Blood: 8.0 mL

Special Processing: Do NOT centrifuge. Specimen is forwarded to Health Sciences Centre MS551 for analysis.
Specimen Stability:
Ambient: Preferred
Refrigerated: Accepted
Frozen: Accepted - must remain frozen
Other comments: Specimens sent for Molecular tests are not to be used for other tests (i.e. CBC).

Referral:

Requisition:

_SH Hereditary Cancer Molecular Requisition (R250-10-10)

Reference Values:

An interpretive report will be sent

Availability:

Within 6 Weeks