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Laboratory: Clinical Biochemistry
Test Name:
Test Code: MISC
Clinical Information:
This test is useful for verifying systemic absorption of orally administered itraconazole.  The test is indicated in patients with life-threatening fungal infections and in patients considered at risk for poor absorption or rapid clearance.  Itraconazole is relatively nontoxic, and a toxic serum threshold has yet to be defined.
Collection Devices:
Gel tube collections are not acceptable.
Specimen Required:

Serum: 1.0 mL
Pediatric Serum: 1.0 mL

Store and ship frozen in a plastic screw cap vial. 
Reference Values:
Itraconazole Trough:  
> 0.5 μg/mL (localized infection)
> 1 μg/mL (systemic infection)
No therapeutic range established; activity and serum concentration are similar to parent drug.
Specific days
Turnaround time expected: within 1 week
See Also:
More Information:
Ship frozen samples to Mayo Medical Laboratories.