MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A (MEN2A) - RET GENE - (B)
Test Code: MD
Testing done for confirmation of clinical diagnosis in patients with a diagnosis of medullar thyroid carcinoma (MTC), pheochromocytoma, parathyroid adenoma or hyperplasia and a positive family history of the MEN2A-related cancers. Testing available for simplex cases when onset of cancer is <35 years of age. Testing involves sequencing of exons 10, 11, 13-16 RET gene. These exons account for 98% of patients with a clinical diagnosis of MEN2.
Testing of asymptomatic relatives available for patients with documented positive family history. Prior consultation with the WRHA Genetics & Metabolism Program is strongly recommended. All out-of-province testing subjected to final laboratory approval. For more information, see:
Blood: 8.0 mL
Pediatric Blood: 3.0 mL
Specimen must be kept at room temperature.
An interpretive report from the reference laboratory will be forwarded to the physician.
Extracted DNA is forwarded to an out-of-province laboratory for testing, if approved. Turnaround time is estimated to be 12 to 14 weeks.
Do NOT centrifuge. Ship blood samples at room temperature to Health Sciences Centre - MS5. Extracted DNA will be forwarded for testing to a reference laboratory. Specimens sent for Molecular tests are not to be used for other tests (ie. CBC).