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Laboratory: Clinical Biochemistry
Test Name:
Test Code: MISC
Clinical Information:
This test is useful for optimizing dosage, assessing toxicity or monitoring compliance of Flecainide. Flecainide (Tambocor) is a class I cardiac antiarrhythmic agent with electrophysiologic properties similar to lidocaine, quinidine, procainamide, and tocainide. The effects of Flecainide are dose-related and plasma concentration-related. 
Flecainide is eliminated from blood by hepatic metabolism as well as renal clearance; significant changes in either organ system will cause impaired clearance. 
Collection Devices:
Do not use separator gel.
Specimen Required:

Serum: 3.0 mL

 Do not use separator gel.
Specimen Required: 3 ml serum. Sample must be centrifuged and serum aliquoted off within 2 hours of collection.

Ship at 4 degrees C
Reference Values:
Therapeutic concentration:  0.2 - 1.0 µg/mL
Toxic concentration:  >1.0 µg/mL
Flecainide is most effective in premature ventricular contractions suppression at plasma concentrations in the range of 0.2 to 1.0 µg/mL.
Plasma concentrations >1.0 µg/mL are associated with a high rate of cardiac adverse experiences such as conduction defects or bradycardia.
Within 1 Week
See Also:
More Information:
Refrigerate sample and send to Mayo Medical Laboratory.