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Laboratory: Clinical Biochemistry
Test Name:
GENTAMICIN - (P)
Test Code: GENT
Clinical Information:
Test Indications: Gentamicin is an aminoglycoside antibiotic used for the treatment of infections caused by gram-negative bacilli. Gentamicin measurement is used to ensure optimal therapeutic levels and to avoid toxicity.
Recommendations: Collect blood for trough concentration within 45 minutes prior to next dose.  When peak concentrations are required, collect blood 20-40 minutes after the end of gentamicin infusion.  
 
Collection Devices:
Do not use separator gel.
Specimen Required:


Plasma: 2.0 mL
Pediatric Plasma: 0.3 mL

Stability 1 week refrigerated, 4 weeks frozen
Referral:

Samples must be transferred to an aliquot tube and stored frozen if analysis will not be complete within 48 hours (#110-10-05 Serum / Plasma Separation Procedure & Transport)


Testing Laboratory (MB): Health Sciences Centre, St. Boniface, Westman, Thompson

Requisition:
Reference Values:
TRADITIONAL DOSE   
Trough:mg/L                   Peak:mg/L                      
Therapeutic:0.5 - 2.0Therapeutic:6.0 - 10.0
Toxic:> 2.0Toxic:> 10.0
    
HIGH DOSE   
Trough:mg/LPeak:mg/L
Therapeutic:< 1.0Therapeutic:14 - 20
(mg/L = μg/mL)   
Availability:
Stat or Routine
See Also:
More Information:
Interpretation & Assay Interferences: Patient samples containing sisomicin will elevate gentamicin results.