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Laboratory: Clinical Biochemistry
Test Name:
Test Code: GENT
Clinical Information:
Test Indications: Gentamicin is an aminoglycoside antibiotic used for the treatment of infections caused by gram-negative bacilli. Gentamicin measurement is used to ensure optimal therapeutic levels and to avoid toxicity.
Recommendations: Collect blood for trough concentration within 45 minutes prior to next dose.  When peak concentrations are required, collect blood 20-40 minutes after the end of gentamicin infusion.  Netilmicin cross-reacts 25% with gentamicin assay.
Collection Devices:
Do not use separator gel.
Specimen Required:

Plasma: 2.0 mL
Pediatric Plasma: 0.3 mL

Stability 1 week refrigerated, 4 weeks frozen

Samples must be transferred to an aliquot tube and stored frozen if analysis will not be complete within 48 hours (#110-10-05 Serum / Plasma Separation Procedure & Transport)
Reference Values:
Trough: mg/L                    Peak: mg/L                      
Therapeutic: 0.5 - 2.0 Therapeutic: 6.0 - 10.0
Toxic: > 2.0 Toxic: > 10.0
Trough: mg/L Peak: mg/L
Therapeutic: < 1.0 Therapeutic: 14 - 20
(mg/L = μg/mL)      
Stat or Routine
See Also:
More Information: