Laboratory: Clinical Biochemistry
Test Name:
APOLIPOPROTEIN B - (S)
Test Code: APB
Clinical Information:
Apolipoprotein B is not useful for the routine screening, diagnosis or treament of lipid disorders and it provides the same information as non-HDL cholesterol which is already part of the lipid profile. Apo B may be useful in diagnosis and treatment follow-up of some individuals with mild to moderate fasting hypertriglyceridemia (2-10 mmol/L). It is useful to measure Apo B in patients with LDL cholesterol results that are <0.3 mmol/L as part of the diagnosis of abetalipoproteinemia. Patients with Apo B values < 0.1 g/L should be referred to a specialist lipid clinic.

Recommendations:
Which Lipids Should be Analyzed for Diagnostic Workup and Follow-up of Patients with Hyperlipidemias? Curr Cardiol Rep. 2018 Aug 17; 20(10):88. doi: 10.1007/s11886-018-1036-1.
Additional practice guideline for adults: 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. Can J Cardiol. 2016; 32 (11): 1263 - 1282
Practice guideline for pediatric/adolescent: Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents Summary Report. 2011; 128 Suppl 5: S213 -- 256 
 
Collection Devices:
Specimen Required:


Serum: 2.0 mL
Pediatric Serum: 0.3 mL

Stability 8 days refrigerated, 2 months frozen
 
Referral:
Serum: 2.0 mL

Samples must be transferred to an aliquot tube and stored frozen if analysis will not be complete within 48 hours (#110-10-05 Serum/Plasma Separation & Transport)
Requisition:
Reference Values:
Adults (>18 yr):
Desirable:  <1.2 g/L
 
Pediatric & Adolescents (<18 yr):
Desirable:  <1.1 g/L
 
Availability:
Within 1 Week
See Also:
More Information: