Laboratory: Clinical Immunology
Test Name:
BETA 2 GLYCOPROTEIN ANTIBODIES (IgM and IgG) - (S)
Test Code: APHL
Clinical Information:
 
Test performed at St. Boniface Hospital Immunology Lab using a multiplex method. 
Phospholipid Antibodies occur in patients with a variety of manifestations (thrombotic events both arterial and venous, obstetric abnormalities: unexplained fetal death, premature birth, placental insufficiency, and severe preeclampsia, cutaneous abnormalies: livido reticularis, pyoderma gangrenosum, and peripheral blood cytopenias, thrombocytopenia, hemolytic anemia).
Diagnosis of antiphospholipid syndrome requires a positive test result of either cardiolipid, B2 Glycoprotein or lupus anticoagulant on more than one occasion separated by at least 6 weeks, in addition to either thrombosis, fetal loss, or thrombocytopenia.
These antibodies are also known to be more frequent in patients with systemic rheumatic diseases.
Antiphospholipid antibodies are also produced in response to infections and as a non-autoimmune epiphenomenom of thrombotic events.
Collection Devices:
Specimen Required:
Blood: 5.0 mL


Serum: 1.0 mL
Referral:
Serum: 1.0 mL

Separate serum; store and ship serum aliquot refrigerated 2 - 8°C.  Do NOT freeze.
Requisition:
Reference Values:
 
Negative:     < 20 U/mL
Low Positive:  20.0 - 39.9 U/mL
Med Positive:  40.0 - 79.9 U/mL
High Positive:  80.0 - 160.0 U/mL
A negative result does not necessarily exclude the disease. Positive results should not be interpreted in isolation and must be correlated with relevant clinical findings.
Availability:
Within 1 Week
See Also:
More Information: