Laboratory: Clinical Biochemistry
Test Name:
Test Code: MISC
Clinical Information:
The clearance studies using 24-hour stool specimens and serum determinations are preferred in order to normalize the large range of serum alpha-1-antitrypsin concentrations and the variability in random stool antitrypsin concentration.  In the absence of either a 24-hour stool collection or a contemporary serum specimen, the fecal concentration of alpha-1-antitrypsin can be used as a surrogate marker.
Collection Devices:
Specimen Required: Homogenized Stool:  1mL           Pediatric Volume:  1mL      

In 1 - Plastic Screw Cap Vial

Store and ship refrigerated or frozen.
Reference Values:
≤ 54 mg/dL
Patients with protein-losing enteropathies generally have alpha-1-antitrypsin stool concentrations > 100 mg/dL.  Borderline elevations above the normal range are equivocal for protein-losing enteropathies.
Within 2 Weeks
See Also:
More Information:
Specimen is referred to Mayo Medical Laboratories for analysis.  Test ID:  A1AF