| Laboratory: | Clinical Biochemistry (SENDOUTS) |
| Test Name: |
IMATINIB - (B)
Test Code:
MIS8
|
| Clinical Information: |
Alternate Name(s): GLEEVEC, GLIVEC, IMATINIB MESYLATE, IMATINIB PLASMA
Description: To monitor the response of treatment of Imatinib in human plasma by liquid chromatography / tandem mass spectrometry (LC-MS/MS).
Test Approval Requirements: Clinical Biochemist Approval Required
Patient preparation instructions: Blood draw must be predose. The blood sample is collected within 12 hours or 24 hours from last dose depending on if the drug is taken twice a day or once a day, respectively. |
| Collection Devices: |
|
| Specimen Required: |
Whole Blood: 4.0 mL
Collect trough specimen, 24 hours post last dose.
Special Processing: Centrifuge and separate within 10 min of collection. Aliquot plasma to a transport tube and indicate date and time of last dose and date and time of specimen collection on the requisition. Do not collect Friday to Sunday or prior to a public holiday. |
| Referral: |
Plasma: 1.0 mL
Referred Out Location: Dynacare
Other comments: Store and ship refrigerated. |
| Requisition: | |
| Reference Values: |
A therapeutic range for Imatinib has not been established.
A review of the literature suggests that maintaining plasma trough concentrations at or above the mean population concentration of ~ 1000 ng/mL could be important for achieving improved cytogenetic and molecular responses.
Method of Analysis: Quantitative Liquid Chromatography Tandem Mass Spectrometry |
| Availability: |
Within 2 Weeks
|
| See Also: | |
| More Information: |
Store and ship samples at 4°C to HSC Clinical Chemistry - MS5 for referral to:
GD Specialized Diagnostics 3885 Industriel Blvd., Laval Quebec H7L 4S3 Samples must be received at GD Specialized Diagnostics within 5 days of collection. |