Laboratory: Clinical Biochemistry  (METABOLIC)
Test Name:
TRANSFERRIN ISOELECTROFOCUSING (TIEF) - (S)
Test Code: TIEF
Clinical Information:
Test Indications:  Screening for N-linked congenital disorders of glycosylation.
 
THIS TEST IS NOT SUITABLE FOR ALCOHOL CONSUMPTION.
 
The congenital disorders of glycosylation (CDG) are a rapidly expanding group of metabolic syndromes with a wide spectrum of symptoms and severity. CDG type I is associated with disruption in the synthesis of the lipid-linked oligosaccharide precursor whereas CDG type II is linked to the malfunctioning trimming/processing of the protein-bound oligosaccharide.
 
This test is qualitative only. This test can NOT pick up rare forms of glycosylation disorders.
 
For an abnormal result, the sample will be sent to a reference lab for quantitation (reflex test). For out of province customer: the billing will be done accordingly.
 
Method: Transferrin isoelectric focusing on a polyacrylamide gel done by Metabolic Lab at HSC.
 
For questions/information: Call Metabolic Lab at 204-787-4530 and ask for the Biochemical Geneticist.  
Collection Devices:
Specimen Required:

Serum:  1.0 mL                          Pediatric:  0.3 mL minimum
 
Stability: see below
Referral:

Store and ship refrigerated or frozen to the Metabolic Lab (HSC).
 
Send a clear copy of the original requisition with the sample.
 
Stability: see below.     
Requisition:
Reference Values:
A descriptive report will be sent.
Availability:
Within 5 Weeks
See Also:
More Information:
If you have any questions, please communicate with the Metabolic Lab (HSC): 204-787-4530
 
Reject due to: Gross hemolysis
 
Stability: 3 months refrigerated or frozen
 
Reflex test send to Mayo Clinic Laboratories
Test ID: CDGN
CPT Code: 83789