DOUBLE NEGATIVE TCR ab T CELLS - (B)

Test Code: PBLS

The laboratory finding of increased TCRab DNT cells in consistent with ALPS only with the appropriate clinical picture (nonmalignant lymphadenopathy, splenomegaly, and autoimmune cytopenias).  Conversely, there are other immunological disorders including common variable immunodeficiency (CVID), which have subsets for patients with this clinical picture, but no increase in TCRab DNT cells.

_SH Flow Cytometry Laboratory Requisition (R250-10-82)

< 3% of CD3 T-cells - adult
< 2% of CD3 T-cells - pediatric (<18 yrs old)
(Reported in addition to the Enumeration Panel.)

Weekdays

LYMPHOCYTE SUBSETS - (B)

Performed by Flow Cytometry at HSC.  Not recommended in lymphopenic states.