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Laboratory: Clinical Immunology
Test Name:
Test Code: MIS8
Clinical Information:
This is not the same as the VEGF-D test which requires Clinical Chemist approval for test referral.
Requires approval prior to collection. Complete the pre-approval form below.
Vascular endothelial growth factor (VEGF) is a critical modulator of angiogenesis (the growth of new blood vessels).  VEGF regulates pathological vessel formation, such as in tumor growth and metastases. Angiogenesis during
tumor development is complex, although it is clear that VEGF plays a key role. VEGF also regulates angiogenesis in other disease states including rheumatoid arthritis (RA), osteoarthritis, diabetes, and age-related macular degeneration. In addition, circulating concentrations of VEGF are elevated in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, a monoclonal plasma cell disorder. Although the pathologic role of VEGF in POEMS is unclear, it is a useful diagnostic marker
for assessing response to therapy.
Collection Devices:
Specimen Required:
Plasma: 0.5 mL

1. Immediately after collection, place the tube on wet ice.
2. Centrifuge at 1500xg for 10 minutes and aliquot plasma.
3. Freeze specimen within 30 minutes.


VEGF has limited stability. Following centrifugation, plasma must be either immediately frozen or refrigerated. Samples can only be stored at refrigerated temperatures for 24 hours, after which time samples must be frozen. Storage of plasma for any length of time at room temperature is not acceptable.
Reference Values:
≤ 96.2 pg/mL
Within 2 Weeks
Restricted. Prior approval required.
See Also:
More Information:
Forward sample to Immunology Laboratory, MS5, HSC for referral to Mayo Clinic Laboratories.