| Laboratory: | Clinical Immunology |
| Test Name: |
ANTI-PHOSPHOLIPASE A2 RECEPTOR (PLA2R) - (S)
Test Code:
PLA2
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| Clinical Information: |
Restricted to Nephrologists or via prior approval.
Complete the pre-approval form by clicking on the following link: http://clients.intelex.com/DSManitobav5/dcDocumentRetrieveExt.asp?sAuth=5e452e805fc5ade05fbae9ab88f227850bb762a71e3575a51efd1362c4724f16&fromDcPublic=1&DocumentID=9467 This test provides semiquantitative in vitro determination of human antibodies of immunoglobulin classes IgG against phospholipase A2 receptor (PLA2R) in patient samples to support the diagnosis of primary membranous nephropathy. Testing is performed at St. Boniface Hospital Immunology Lab using an indirect Immunofluorescence assay (IFA). Serum samples are initially screened at a 1:10 dilution utilizing slides coated with transfected cells. A titre increase, decrease or disappearance precedes a change in the clinical status. Thus, the quantitative determination has a high predictive value with respect to clinical remission or relapse and risk estimation after kidney transplantation. The success of therapy can be assessed by means of of the anti-PLA2R titre. |
| Collection Devices: |
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| Specimen Required: |
Blood: 5.0 mL
Serum: 1.0 mL
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| Referral: |
Serum: 1.0 mL
Separate serum and ship refrigerated, or frozen if greater than 7 days from time of collection.
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| Requisition: | |
| Reference Values: |
<1:10 TITRE (Negative)
Positive results will be accompanied with a titre. A diagnosis should not be made based on a single test result. The clinical symptoms of the patient should always be taken into account along with the serological results by the physician. |
| Availability: |
Weekdays
TAT 5-7 days. Restricted to Nephrologists or prior arrangement only.
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| See Also: | |
| More Information: |