Laboratory: Clinical Immunology
Test Name:
FREE LIGHT CHAINS (SERUM) - (S)
Test Code: FLCH
Clinical Information:
The detection of immunoglobulin-free light chains in serum is important in the diagnosis, prognosis and management of patients with plasma dyscrasias.  In addition, the short physiological half life of sFLC in blood (kappa: 2-4 h and lambda: 3-6 h) allows this to be used as a serum marker for real-time monitoring of response to treatment as well as disease progresssion.
The specificity of this assay for detection of monoclonal light chains relies on the ratio of free kappa and lambda (K/L) light chains.  Elevated kappa and lambda (K/L) free light chain (FLC) may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance.  A specific increase in FLC K/L ratio must be demonstrated for diagnostic purposes.
Test performed at:  HSC Immunology Laboratory, MS5
Analyzed twice per week, with a turn-around-time of no more than 5 working days.
 
Collection Devices:
Specimen Required:
Blood: 4.0 mL


Serum: 1.0 mL
Referral:
Requisition:
Reference Values:
Normal Ranges:
Free Kappa Light Chains:              3.30 - 19.40 mg/L
Free Lambda Light Chains:           5.71 - 26.30 mg/L
Free Kappa/Free Lambda Ratio:  0.26 - 1.65
Availability:
Specific days
See Also:
More Information: