| Laboratory: | Clinical Biochemistry (AUTOMATED) | ||||
| Test Name: |
TRIPTORELIN STIMULATION TEST- FEMALE - (P)
Test Code:
TSTF
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| Clinical Information: |
Description: The gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for diagnosing central precocious puberty (CPP). Gonadorelin (synthetic GnRH) is no longer available and triptorelin is now used as an alternative (Jan 2025).
Response is evaluated by measuring LH and FSH at 0, 15, 30, 60, 90, 120 and 180 min; estradiol is measured at 0 and 180 min.
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| Collection Devices: |
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| Specimen Required: |
Plasma: 1.0 mL
Pediatric Plasma: 0.4 mL
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| Referral: |
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| Requisition: | |||||
| Reference Values: |
Reference Intervals: LH level greater than or equal to 3.4 IU/L is suggestive of central precocious puberty.
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| Availability: |
Endocrinology Consult Required
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| See Also: | |||||
| More Information: |
References:
• Kim, Yu & Hwangbo, Jung & Park, Kyu & Kang, Eungu & Nam, Hyo-Kyoung & Rhie, Young-Jun & Lee, Kee-Hyoung. (2024). Effectiveness of the triptorelin stimulation test compared with the classic gonadotropin-releasing hormone stimulation test in diagnosing central precocious puberty in girls. Annals of pediatric endocrinology & metabolism. 29. 90-94. 10.6065/apem.2346054.027. • Vukovic, R., Milenkovic, T., Soldatovic, I. et al. Triptorelin stimulated luteinizing hormone concentrations for diagnosing central precocious puberty: study of diagnostic accuracy. Endocrine 75, 934–941 (2022). https://doi-org.uml.idm.oclc.org/10.1007/s12020-021-02947-z • Ahn J, Lee Y, Gim S, Jeong H. Use of the Subcutaneous Triptorelin Stimulation Test for Diagnosis of Central Precocious Puberty. Children. 2023; 10(11):1830. https://doi.org/10.3390/children10111830 • Freire, A.V., Escobar, M.E., Gryngarten, M.G., Arcari, A.J., Ballerini, M.G., Bergadá, I. and Ropelato, M.G. (2013), High diagnostic accuracy of subcutaneous Triptorelin test compared with GnRH test for diagnosing central precocious puberty in girls. Clin Endocrinol, 78: 398-404. https://doi-org.uml.idm.oclc.org/10.1111/j.1365-2265.2012.04517.x |