| Laboratory: | Clinical Biochemistry | ||||
| Test Name: |
CREATININE - (U)
Test Code:
CRU
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| Clinical Information: |
Chronic kidney disease carries a substantial risk for cardiovascular morbidity and mortality. Chronic kidney disease is defined as kidney damage or glomerular filtration rate (GFR) less than 60 mL/minute per 1.73 m2 for three months or more. The assay of plasma creatinine is the most commonly used test to assess renal function. It is a breakdown product of creatine phosphate in muscle, and is produced at a fairly constant rate by the body. It is freely filtered by the glomeruli and is not reabsorbed by the tubules. A small but significant amount is also actively secreted. In addition to the diagnosis and treatment of renal disease and monitoring of renal dialysis, creatinine measurements are used for the calculation of the fractional excretion of other urine analytes (e.g. albumin).
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| Collection Devices: |
24h urine collected without preservative preferred. Refrigerate 24h and random urine specimens until analysis.
Similar lab approved leak-proof containers acceptable. |
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| Specimen Required: |
Urine: 3.0 mL
Stable 6 days refrigerated, 6 months frozen |
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| Referral: | |||||
| Requisition: | |||||
| Reference Values: |
≥ 19 y: 8.0-16.0 mmol/d
(mmol/d x 113.1 = mg/d) < 19 y: 0.13-0.22 mmol/kg/d (mmol/kg/d x 113.1 = mg/kg/d) |
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| Availability: |
Stat or Routine
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| See Also: | |||||
| More Information: |
If random urine, specify.
If 24 h urine, measure and record volume. Refrigerate 24h and random urine specimens until analysis. |