MYCOPHENOLIC ACID (MPA) - (P)

Test Code: MYPA

Description: Mycophenolic acid (MPA) is an active metabolite of mycophenolate mofetil (MMF), an immunosuppressant medication used to prevent transplant rejection. It is typically used in combination with calcinurine inhibitors and steroids. MPA is a selective, noncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme in de novo synthesis of guanosine.
Test Indications: Monitoring of MPA levels can be useful immediately after therapy is initiated (up to 3 weeks) or upon major changes in health status.
It is important to note that effective therapeutic range depends on numerous factors, including type of transplant, time post-transplant, patient's clinical status (e.g. organ function), and co-medication.

Gel tubes are not acceptable. Serum (red top, no gel) is acceptable.

_SH Biochemistry Hematology Requisition (R250-10-92)

_SH Hospital Biochemistry Hematology Non Winnipeg Brandon (R250-10-91)

_SH Winnipeg Brandon Biochemistry Hematology Requisition (R250-10-94)

_SH Winnipeg Brandon Hospital Biochemistry Hematology Requisition (R250-10-93)

Reference Intervals: 
Therapeutic range (trough):  1.0 - 3.5 mg/L
Toxic range: >25.0 mg/L
 
*Trough: just before the next regular dose; steady-state: 3-5 days at the same dose 
 
Specimens collected outside of steady-state trough period in the dosing cycle are likely to have higher MPA levels and trough therapeutic range should not be applied.
Method of Analysis: LC-MS/MS (Laboratory Developed Test)

Once Per Week

Test is performed at HSC every Friday. For same day analysis, samples must be received at HSC prior to 12 pm on Friday.

References: Bergan S et al. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Ther Drug Monit. 2021 Apr 1;43(2):150-200.