| Laboratory: | Clinical Biochemistry (SPECIAL CHEMISTRY) | ||||||||||||
| Test Name: |
RENIN DIRECT (MASS, CONCENTRATION) - (P)
Test Code:
RENI
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| Clinical Information: |
Test Indications: Investigating primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (eg, renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome).
See Hypertension Canada’s 2020 Guidelines for more information.
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| Collection Devices: |
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| Specimen Required: |
Plasma: 1.0 mL
Collection Information: · The recommended collection time is 7-10 a.m., after the patient is active (walking, standing, seating) for at least 2 hours. Patient must be seated for 5-15 min prior to collection. · Collect EDTA plasma. Serum or lithium heparin plasma are not acceptable. · Do not pre-chill EDTA blood collection tubes nor store tubes on ice, but process blood at room temperature to avoid cryoactivation of prorenin in renin testing. · Centrifuge tubes in a non-refrigerated centrifuge, separate EDTA-plasma from cells immediately after centrifugation, then aliquot and deep-freeze at -20 °C or below instantly. Specimen Stability: Ambient: 6 hours Refrigerated: not stable Frozen: 3 days at -20oC or at least 1 month at -80°C
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| Referral: |
Plasma: 1.0 mL
Pediatric Plasma: 0.8 mL
Shipping & Storage: Store and ship frozen. Preferably on dry ice if available.
Testing Laboratory (MB): Send specimen to Health Sciences Centre - MS5
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| Requisition: | |||||||||||||
| Reference Values: |
Reference Intervals:
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| Availability: |
Within 1 Week
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| See Also: | |||||||||||||
| More Information: |
Interpretation & Assay Interferences: The assay is not affected by concentrations of bilirubin up to 40 mg/dL, hemoglobin up to 600 mg/dL, or triglycerides up to 3000 mg/dL.
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