Laboratory: Clinical Biochemistry
Test Name:
Test Code: ALT
Clinical Information:
The enzyme alanine aminotransferase (ALT) is present in a variety of tissues (including liver, kidney & heart). The major source of ALT is the liver, which has led to the measurement of ALT activity for the diagnosis of hepatic diseases. Elevated serum ALT is found in hepatitis, cirrhosis, obstructive jaundice, carcinoma of the liver, and chronic alcohol abuse.
Although both serum aspartate aminotransferase (AST) and ALT become elevated whenever disease processes affect liver cell integrity, ALT is the more liver-specific enzyme and elevations persist longer than elevations of AST activity.
Collection Devices:
Specimen Required:

Plasma: 2.0 mL

Stability 7 days refrigerated, Greater than 7 days at -70 degrees
Serum: 2.0 mL

Samples must be transferred to an aliquot tube and stored frozen if analysis will not be complete within 48 hours (#110-10-05 Serum / Plasma Separation Procedure & Transport)
Reference Values:
0 - 12 mo:   < 42 U/L
13 mo - 12 y: 4 - 30
Male ≥ 13 y:   < 30
Female ≥ 13 y:   < 25
Note:  Reference ranges are specific to instrumentation/site where testing performed.  For testing performed at different sites (other than WRHA & Westman Labs), please refer to the appropriate Lab Information Manual (LIM) entry.
Stat or Routine
See Also:
More Information: