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Laboratory: Clinical Biochemistry  (AUTOMATED)
Test Name:
Test Code: LIPP
Clinical Information:
Test Indications: High density lipoproteins (HDL) are responsible for the transport of cholesterol from peripheral cells to the liver for excretion. HDL cholesterol testing is used in combination with total cholesterol and triglyceride determination for atherosclerotic risk assessment as well as in the diagnosis and monitoring of lipid and lipoprotein metabolic disorders.
An individual’s level of risk for cardiovascular disease associated with their lipoprotein profile should be managed according to current practice guidelines. Therapy thresholds and targets are based on current guidelines.

Canadian Cardiovascular Society Dyslipidemia Guidelines
Adult: 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults
Pediatrics: The Detection, Evaluation, and Management of Dyslipidemia in Children and Adolescents: A Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Clinical Practice Update (2022)

Patient Preparation Instructions: Fasting or non-fasting specimen, as requested by the ordering physician.
If fasting specimen is required:
Adult: fast 8-12 hours
Infant: collect just before next feeding

Lipid Reporting and NIH LDL-C Equation Update by Shared Health and Dynacare Laboratories
Collection Devices:
Collect from a sitting position after a 10 minute rest period.
Specimen Required:

Plasma: 2.0 mL
Pediatric Plasma: 1.0 mL

Specimen Stability:
Ambient: 3 days
Refrigerated: 7 days
Frozen:  3 months
Plasma: 2.0 mL

Shipping & Storage: Aliquot, store and ship frozen. Refer to SOP# 1110-10-05 Serum Plasma Separation Procedure and Transport
Reference Values:
Age Gender Decision Limit Comment
<20 y All ≥1.00 mmol/L
Desired: >1.20 mmol/L
Borderline: 1.00 - 1.20 mmol/L
Increased risk:  <1.00 mmol/L
HDL-C <0.30 mmol/L may be associated with genetic dyslipidemias. Refer to specialist.
≥20 y Male ≥1.00 mmol/L
HDL-C < 1.00 mmol/L indicates risk for metabolic syndrome.
≥20 y Female ≥1.30 mmol/L
HDL-C < 1.30 mmol/L indicates risk for metabolic syndrome.

Method of Analysis: Roche Cobas or Ortho Vitros
Stat or Routine
See Also:
More Information:
Interpretation & Assay Interferences: Refer to individual tests for assay interference.