Laboratory: | Clinical Biochemistry (SPECIAL CHEMISTRY) | ||||||||||||||
Test Name: |
VANILLYLMANDELIC ACID (VMA), RANDOM OR 24H URINE - (U)
Test Code:
VMA
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Clinical Information: |
Description: Homovanillic acid (HVA) and vanillylmandelic acid (VMA) are the preferred tests for screening for neuroblastoma in a random urine specimen.
Supporting neuroblastoma diagnosis & monitoring patients with a treated neuroblastoma.
HVA and VMA tests are performed and reported as a panel.
Elevated HVA and VMA values are suggestive of a pheochromocytoma, but they are not diagnostic. For investigation of PHEOCHROMOCYTOMA in adults, the test FRACTIONATED METANEPHRINES - (U) should be ordered only. Numerous over-the-counter and herbal products/supplements may affect VMA levels and should be discontinued for 72 hours prior to collection. |
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Collection Devices: |
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Specimen Required: |
Urine: 10.0 mL
Pediatric Urine: 1.0 mL
Collection Information: If collecting 24h urine, refrigerate during collection. If collecting random urine, morning void is preferred. For details refer to |
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Referral: |
Urine: 10.0 mL
Pediatric Urine: 1.0 mL
Shipping & Storage: Store and ship frozen.
Testing Laboratory (MB): HSC Clinical Biochemistry Mass Spectrometry/Metabolic Lab (204)-787-4530 |
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Requisition: | |||||||||||||||
Reference Values: |
Slight or moderate increases in catecholamine metabolites may be due to extreme anxiety, essential hypertension, intense physical exercise, or drug interactions. Significant increase of one or more catecholamine metabolites (several times the upper reference limit) is associated with an increased probability of a secreting neuroendocrine tumor. |
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Availability: |
Within 10 Days
For urgent testing, consult Clinical Biochemist of Duty 431-276-4861
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See Also: | |||||||||||||||
More Information: |
Interpretation & Assay Interferences: Medications that may interfere with catecholamines and their metabolites include amphetamines and amphetamine-like compounds, appetite suppressants, bromocriptine, buspirone, caffeine, chlorpromazine, clonidine, disulfiram, diuretics (in doses sufficient to deplete sodium), epinephrine, glucagon, guanethidine, histamine, hydrazine derivatives, imipramine, levodopa (L-dopa, Sinemet), lithium, MAO inhibitors, melatonin, methyldopa (Aldomet), morphine, nitroglycerin, nose drops, propafenone (Rythmol), radiographic agents, rauwolfia alkaloids (Reserpine), tricyclic antidepressants, and vasodilators. The effects of some drugs on catecholamine metabolite results may not be predicable.
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