| Laboratory: | Clinical Biochemistry (BIOCHEMICAL GENETICS) | ||||
| Test Name: |
HOMOCYSTEINE, TOTAL by LC-MS/MS - (P)
Test Code:
HCQ
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| Clinical Information: |
Test Indications: Elevations in plasma homocysteine are commonly found as a result of vitamin deficiencies (pyridoxal, folate, riboflavin, B12), polymorphisms of enzymes of methionine metabolism, and renal disease.
Severely elevated concentrations of total homocysteine are found in subjects with homocystinuria, a rare genetic disorder of the enzymes involved in the metabolism of homocysteine |
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| Collection Devices: |
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| Specimen Required: |
Plasma: 1.0 mL
Pediatric Plasma: 0.5 mL
Collection Information: Immediately place specimen on wet ice and send to the lab Special Processing: It is important to centrifuge blood samples immediately (<20 min) after collection to separate the plasma from the blood cells. If immediate centrifugation is not possible, collect on ice and centrifuged within an hour. Aliquot immediately. Specimen Stability: Ambient: N/A Refrigerated: 1 month (separated from cells) Frozen: 6 months |
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| Referral: |
Shipping & Storage: Store and send refrigerated or frozen. Specimen not received on ice will be rejected.
Testing Laboratory (MB): HSC (Health Sciences Centre) – Biochemistry MS5 Biochemical Genetics Lab / Metabolic Lab Inquiries: 204-787-4530 |
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| Requisition: | |||||
| Reference Values: |
Reference Intervals: 4.5 - 13 μmol/L
Method of Analysis: Liquid Chromatography Tandem Mass Spectrometry |
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| Availability: |
Within 1 Week
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| See Also: | |||||
| More Information: |
Interpretation & Assay Interferences: Hemolysis, lipemia and icterus do not interfere with assay.
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