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Laboratory: Clinical Immunology
Test Name:
Test Code: TTGA
Clinical Information:
Testing is performed at St. Boniface Hospital Immunology Lab using an indirect Immunofluorescence assay (IFA).  Testing is ONLY performed as a reflex test for samples with a positive tTG IgA.Serum samples are initially screened at a 1:10 dilution.
This test kit is designed for the semiquantitative in vitro determination of human antibodies of immunoglobulin classes IgA against endomysium in patient samples for the diagnosis of gluten-sensitive enteropathy (GSE; young children: coeliac disease, adults: nontropical sprue) and Duhring's dermatitis herpetiformis.
Collection Devices:
Specimen Required:
Blood: 5.0 mL

Serum: 1.0 mL
Serum: 1.0 mL

Separate serum and ship refrigerated, or frozen if greater than 7 days from time of collection.
Reference Values:
AEMA:  <1:10 Titre (Negative)
A negative result does not necessarily exclude autoimmune disease.  Positive results should not be interpreted in isolation and must be correlated with relevant clinical findings.
Laboratory Hours of Operation: Mon-Fri, 0800-1615, excluding holidays. AEMA TAT: within 4 days
See Also:
More Information:
Positive results will also be accompanied by a Titre.
Note: Levels may become undetectable after a gluten free diet is initiated.