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Laboratory: Clinical Immunology
Test Name:
ENDOMYSIAL ANTIBODY (IgA) - (S)
Test Code: TTGA
Clinical Information:
Testing is performed at St. Boniface Hospital Immunology Lab using an indirect Immunofluorescence assay (IFA).  Testing is performed as a reflex for samples with a positive tTG IgA (initial positive ONLY). Serum samples are initially screened at a 1:10 dilution. 


Samples with tTG IgA ≥200 RU/ml will not reflex to AEMA as there is >99% agreement between tTG IgA and AEMA at this threshold. 
 
This test kit is designed for the semiquantitative in vitro determination of human antibodies of immunoglobulin classes IgA against endomysium in patient samples for the diagnosis of gluten-sensitive enteropathy (GSE; young children: coeliac disease, adults: nontropical sprue) and Duhring's dermatitis herpetiformis.
 

Collection Devices:
Specimen Required:
Blood: 5.0 mL


Serum: 1.0 mL
Referral:
Serum: 1.0 mL

Separate serum and ship refrigerated, or frozen if greater than 7 days from time of collection.
Requisition:
Reference Values:
AEMA:  <1:10 Titre (Negative)
 
A negative result does not necessarily exclude autoimmune disease.  Positive results should not be interpreted in isolation and must be correlated with relevant clinical findings.
Availability:
Weekdays
Laboratory Hours of Operation: Mon-Fri, 0800-1615, excluding holidays. AEMA TAT: within 4 days
See Also:
More Information:
Positive results will also be accompanied by a Titre.
 
Note: Levels may become undetectable after a gluten free diet is initiated.