Lab Information Manual

Laboratory:

Genomics (MOLECULAR DIAGNOSTICS)

Test Name:

Lynch syndrome- MLH1 gene Mennonite variant (c.2141G>A, p.Trp714Ter) - (B)

Test Code: MD

Clinical Information:

Description: One selected gene variant in MLH1 (variant-c.2141G>A, p.Trp714Ter) is found in some Manitoba Mennonite families.
This testing will not detect variants outside of the regions examined
Ordering restricted to: Medical Genetics
Recommendations: Testing is limited to Medical genetics

Collection Devices:

Preferred Device:

2 - EDTA 4 mL NO GEL Tube(s) - Full Tube Collection

EDTA 4 mL NO GEL Tube(s) - Full Tube Collection
Manufacturer: Becton Dickinson & Company

Catalogue #: 367861

Specimen Required:

Whole Blood: 8.0 mL

Special Processing: Do NOT centrifuge. Specimen is forwarded to Health Sciences Centre MS551 for analysis.
Specimen Stability:
Ambient: Preferred
Refrigerated: Accepted
Frozen: Accepted - must remain frozen
Other comments: Specimens sent for Molecular tests are not to be used for other tests (i.e. CBC).

Referral:

Requisition:

_SH Hereditary Cancer Molecular Requisition (R250-10-10)

Reference Values:

An interpretive report will be sent.

Availability:

Weekdays

Routine TAT is 12 weeks. STAT TAT 4-6 weeks may be requested following laboratory consultation.