Laboratory: Clinical Immunology
Test Name:
Test Code: APHL
Clinical Information:
Test performed at St. Boniface Hospital Immunology Lab using  multiplex method.
Phospholipid Antibodies occur in patients with a variety of manifestations (thrombotic events both arterial and venous, obstetric abnormalities: unexplainted fetal death, premature birth, placental insufficiency, and severe preeclampsia, cutaneous abnormalies: livido reticularis, pyoderma gangrenosum, and peripheral blood cytopenias, thrombocytopenia, hemolytic anemia).
Diagnosis of antiphospholipid syndrome requires a positive test result of either cardiolipid, β2 Glycoprotein or lupus anticoagulant on more than one occasion separated by at least 6 weeks, in addition to either thrombosis, fetal loss, or thrombocytopenia.
These antibodies are also known to be more frequent in patients with systemic rheumatic diseases.
Antiphospholipd antibodies are also produced in response to infections and as a non-autoimmune epiphenomenom of thrombotic events.
The tests listed below are recommended for integrated investigation of anti-phospholipid syndrome.
Collection Devices:
Specimen Required:
Blood: 5.0 mL

Serum: 1.0 mL
Serum: 1.0 mL

Separate serum; store and ship serum aliquot refrigerated 2 - 8°C.  Do NOT freeze.
Reference Values:
Negative < 20 U/mL
A negative result does not necessarily exclude the disease.  Positive results should not be interpreted in isolation and must be correlated with relevant clinical findings.
Within 1 Week
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