| Laboratory: | Clinical Immunology |
| Test Name: |
ALPHA-1-ANTITRYPSIN - (S)
Test Code:
AATD
|
| Clinical Information: |
Alternate Name(s): Prolastin, AAT (Alpha-1-Antitrypsin), A1-Antitrypsin, A1A, Anti-Alpha-1-Trypsin
Measurement of alpha1-antitrypsin aids in the diagnosis of juvenile and adult cirrhosis of the liver. Alpha1-antitrypsin deficiency has been associated with neonatal respiratory distress syndrome, severe protein-losing disorders, and pulmonary emphysema. Values should be used in conjunction with other laboratory and clinical findings. |
| Collection Devices: |
Preferred Device:
|
| Specimen Required: |
Serum: 1.0 mL
Refrigerated: 14 days Frozen: 30 days |
| Referral: |
Serum: 1.0 mL
Shipping & Storage: Separate serum and ship refrigerated.
Testing Laboratory (MB): Health Sciences Centre Immunology Laboratory |
| Requisition: | |
| Reference Values: |
Adult 19+: 0.90 – 2.00 g/L
Adult reference values adopted from Binding Site, Optilite Alpha-1-Antitrypsin Kit, INS034.OPT, ver 30th September 2020. Reference values have not been established for patients that are less than 19 years of age. Method of Analysis: Turbidimetry – Binding Site Optilite |
| Availability: |
Within 1 Week
|
| See Also: | |
| More Information: |
If sample requirements are met, patients with quantitative results below 0.900 g/L will be sent to In-Common Laboratories for Proteotype testing. If the mass spectrometry proteotype and quantitative serum levels are discordant, phenotyping will be added and reported.
Reportable Range: 0.35 – 5.00 g/L High levels of alpha-1-antitrypsin may be present in patients with acute inflammation. |