| Laboratory: | Clinical Biochemistry |
| Test Name: |
THIOPURINE METHYLTRANSFERASE (TPMT) GENOTYPING - (B)
Test Code:
MIS8
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| Clinical Information: |
Test Indications: This test may be used as an alternate testing for acute thiopurine toxicity in patients who received multiple red blood cell transfusions prior to testing.
NOTE: only screens for common mutations. Recommended screening test for azathioprine and 6-mercaptopurine induced leucopenia is Thiopurine Methyltransferase (TPMT), Enzyme Activity (Phenotype), Erythrocytes – (B) https://apps.sbgh.mb.ca/labmanual/test/view?seedId=5403 (test code: TPMP) Test Approval Requirements: F260-11-02 Biochemistry Approval for Test Referral Form Exception: Test approval is not required for requests from Oncology specialists. |
| Collection Devices: |
Preferred Device:
Transport specimen to lab on ice (to prevent specimen from freezing, wrap specimen in paper towel and place on ice). Patients should be tested prior to azathioprine or 6-MP administration.
|
| Specimen Required: |
Whole Blood: 3.0 mL
Pediatric Whole Blood: 3.0 mL
Collection Information: 1. Invert several times to mix blood. 2. Send whole blood specimen in original tube. Do not aliquot. Collection Information: Do not centrifuge. Do not freeze. Specimen Stability: Ambient: 24 hours Refrigerated: 7 days Frozen: unacceptable |
| Referral: |
Whole Blood: 3.0 mL
Shipping & Storage: Send in original collection tube. Store and ship whole blood at room temperature (preferred) or refrigerated. Do not freeze.
Specimen must be received at the testing site within 7 days of collection. Referred Out Location: Specimen referred from HSC-MS5 to: In-Common Laboratories (ICL) 57 Gervais Drive North York, Ontario M3C 1Z2 Telephone: (416) 422-3000 Test ID: TPMTGENO Test Name: Thiopurine Methyltransferase (TPMT) Genotype, Blood Testing location: Sunnybrook Hospital, Toronto, ON, Canada |
| Requisition: | |
| Reference Values: |
An interpretive report will be provided.
Method of Analysis: PCR |
| Availability: |
Within 3 Weeks
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| See Also: | |
| More Information: |