Laboratory: Clinical Biochemistry
Test Name:
CAH COMPREHENSIVE PROFILE (6) - (S)
Test Code: MIS8
Clinical Information:
THIS TEST IS NOT MEANT TO BE A SCREENING FOR CONGENITAL ADRENAL HYPERPLASIA (CAH). IT IS TO BE USED FOR THE FOLLOWING INDICATIONS UNDER THE DIRECTIONS OF ENDOCRINOLOGIST:
 
1.         Ambiguous genitalia or unexplainable electrolyte results in infancy
2.         Premature sexual development in older children
3.         Hirsutism and irregular menses in adult females
 
No special patient preparation required.
Collection Devices:
Preferred Device:
Alternate Device:
1 - Microtainer(s) - Plain Serum, NO GEL (0.5 mL) to fill line
Serum gel tube is not acceptable.
Specimen Required:


Serum: 3.5 mL
Pediatric Serum: 2.0 mL

Note:  Minimum volume for pediatric samples only.  Minimum volume does not allow for repeat analysis.
Referral:
Serum: 3.5 mL
Pediatric Serum: 2.0 mL

Serum collected WITHOUT separator gel in aliquot tube shipped in on ice.
Adult: minimum 3.5 mL
Pediatric : minimum 2.0 mL
 
Store and ship serum frozen.
Spin down and separate serum within 1 hour of collection.
Requisition:
Reference Values:
Method of Analysis: High Pressure Liquid Chromatography/Tandem Mass Spectrometry (HPLC/MS-MS)

Reference values for age and gender will be given with report. Complete details of the reference values are available at https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/75305

 
Availability:
Within 2 Weeks
Ordering restricted to endocrinologists - authorized physicians only
See Also:
More Information:
Store and send frozen to HSC Clinical Chemistry MS5. Specimen is referred to Mayo Medical Laboratories for analysis. Test ID: FFCAH
 
Spin down and separate serum within 1 hour of collection.
 
 
References:
 
1.   Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, Meyer-Bahlburg HF, Miller WL, Montori VM, Oberfield SE, Ritzen M, White PC, Endocrine Society. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010; 95(9): 4133-60.
 
2.    Lambert SM, Vilain EJ, Kolon TF. A practical approach to ambiguous genitalia in the newborn period. Urol Clin North Am. 2010; 37(2): 195-205.
 
3.    Antal Z, Zhou P. Congenital adrenal hyperplasia: diagnosis, evaluation, and management. Pediatr Rev. 2009; 30(7): e49-57.
 
4.    Witchel SF. Nonclassic congenital adrenal hyperplasia. Curr Opin Endocrinol Diabetes Obes. 2012; 19(3): 151-8.