Laboratory: Clinical Biochemistry  (AUTOMATED)
Test Name:
CREATININE - (P)
Test Code: CR
Clinical Information:
Chronic kidney disease carries a substantial risk for cardiovascular morbidity and mortality. Chronic kidney disease is defined as kidney damage or glomerular filtration rate (GFR) less than 60 mL/minute per 1.73 m2 for three months or more. The assay of plasma creatinine is the most commonly used test to assess renal function. It is a breakdown product of creatine phosphate in muscle, and is produced at a fairly constant rate by the body. It is freely filtered by the glomeruli and is not reabsorbed by the tubules. A small but significant amount is also actively secreted. In addition to the diagnosis and treatment of renal disease and monitoring of renal dialysis, creatinine measurements are used for the calculation of the fractional excretion of other urine analytes (e.g. albumin).
Test Indications:
eGFR CKD-EPI (equation) will be reported automatically with all creatinine results for outpatients (excludes Emergency) or referred-in specimens.  For hospital inpatients or Emergency patients, eGFR will not be reported unless specifically requested by ordering test code EGFR.
 
For more information on eGFR, see http://www.kidneyhealth.ca/wp/?s=egfr&searchsubmit=Find
 
For Manitoba Renal Program Kidney Disease Referral Pathways, see http://www.kidneyhealth.ca/wp/healthcare-professionals/egfr-referral-pathways/

Recommendations:
Clinical Practice Change - eGFR using CKD-EPI equation. https://dsmanitoba.ca/wp-content/uploads/2018/01/eGFR-2018-CPC-26-Jan-2018.pdf
Collection Devices:
Specimen Required:


Plasma: 2.0 mL
Pediatric Plasma: 0.2 mL

Stability 7 days refrigerated, 3 months frozen
Referral:
Serum: 2.0 mL

Samples must be transferred to an aliquot tube and stored frozen if analysis will not be complete within 48 hours (#110-10-05 Serum / Plasma Separation Procedure & Transport)
Requisition:
Reference Values:
0 - 4 wk:             27-88 µmol/L
5 wk - 5 y:          18-35 µmol/L
6 - 12 y:              27-62 µmol/L
13 - 18 y:            44-88 µmol/L
Female ≥ 19 y:   35-97 µmol/L
Male ≥ 19 y:       44-106 µmol/L
Availability:
Stat or Routine
See Also:
More Information: