| Laboratory: | Clinical Biochemistry (SENDOUTS) | ||||
| Test Name: |
COPEPTIN - (P)
Test Code:
MIS8
|
||||
| Clinical Information: |
Alternate Name(s):ADH, Antidiuretic hormone, vasopressin, arginine vasopressin, AVP, ProAVP
Description: Copeptin is a surrogate marker for arginine vasopression (AVP, anti-diuretic hormone, ADH) release. Copeptin and ADH are derived from the same pre-provasopressin precursor peptide. Unlike ADH, which is released in pulsatile patterns and rapidly removed from plasma, copeptin levels in plasma are relatively steady. Plasma copeptin specimens are very stable in comparison to ADH and are easy to measure by fluorescent immunoassay. Copeptin testing has now replaced ADH for the differential diagnosis of polyuria-polydipsia syndrome and distinguishes between central and nephrogenic diabetes insipidus (DI). Patient preparation instructions: Discontinue diuretic or antidiuretic medications for at least 24 hours before test. |
||||
| Collection Devices: |
Red, Gold, or Lavender (EDTA) top tubes are also acceptable.
|
||||
| Specimen Required: |
Serum: 1.0 mL
Pediatric Serum: 0.5 mL
Collect full tube to measure copeptin and osmolality on the same sample. Store and ship frozen Specimen Stability: Ambient: 3 days Refrigerated: 3 days Frozen: 90 days
|
||||
| Referral: |
Adult Volume: 0.5 mL (two tubes)
Pediatric Volume: 0.3 mL (two tubes) Shipping & Storage: Store and ship frozen. Referred Out Location: Specimen referred from HSC-MS5 or SBH to: In-Common Laboratories 57 Gervais Drive North York, Ontario M3C 1Z2 Telephone: (416) 422-3000 Test ID: COPEPTIN Testing location: London Health Sciences, London, ON |
||||
| Requisition: | |||||
| Reference Values: |
Reference Intervals: See ICLabs website for interpretation.
Method of Analysis: BRAHMS Copeptin proAVP KRYPTOR |
||||
| Availability: |
Within 2 Weeks
|
||||
| See Also: | |||||
| More Information: |