|Laboratory:||Clinical Biochemistry (SENDOUTS)|
Nudix Hydroxylase (NUDT15) Genotyping - (B)
Test Code: MISC
Test Indications: This test must be approved by a Clinical Chemist prior to sendout.
Click here for the Approval for Test Referral Biochemistry form (F260-11-02)
This test is used for assessment of patients with acute lymphoblastic leukemia (ALL) at risk of acute thiopurine toxicity and who are of indigenous and asian descent.
NUDT15 testing is used for predicting potential for toxicity to thiopurine drugs (6-mercaptopurine, 6-thioguanine and azathioprine).
This test includes genotyping of TPMT and NUDT15, both of which affect metabolism of thiopurine drugs.
Alternate Name: Thiopurine Methyltransferase (TPMT) and Nudix Hydrolase (NUDT15) Genotyping
Recommendations: Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update. Clinical Pharmacology and Therapeutics 2019, 105(5): 1095-1105
Clinical Information Document Link: https://cpicpgx.org/guidelines/guideline-for-thiopurines-and-tpmt/
Blood: 6.0 mL
Pediatric Blood: 4.0 mL
Stability 9 days room temperature, 30 days refrigerated.
A descriptive report will be sent.
Within 2 Weeks
Available to Pediatric Oncologists for assessment of patients with acute lymphoblastic leukemia (ALL) at risk of acute thiopurine toxicity and who are of indigenous and asian descent.
Send specimen in original collection tube to HSC Clinical Biochemistry Lab MS551. Specimen will be forwarded to Mayo Medical Laboratories for testing. Store and ship whole blood at room temperature (preferred) or refrigerated.
Test ID: TPNUV (0034U)