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Laboratory: Clinical Biochemistry  (AUTOMATED)
Test Name:
THYROXINE, FREE (FREE T4) - (P)
Test Code: FT4
Clinical Information:
Description: FT4 is available as a component of the Thyroid Reflex Testing protocol when TSH is <0.4 mU/L or >4.2 mU/L.

 

Ordering FT4 and/or FT3 outside of reflex testing is restricted.

1)      FT4 can be ordered using “General Endocrinology Requisition” and indicating reason for ordering

OR

2)      FT4 and FT3 can be ordered using “Specialized Endocrinology Requisition ” by pre-approved physicians only.

Test Indications:  FT4 and/or FT3 testing should only be ordered directly for patients:

·        With known or suspected pituitary/hypothalamic disease

·        Treated for primary hyperthyroidism, severe hyperthyroidism (thyroid storm), or severe hypothyroidism (myxedema coma)

·        Known resistance to thyroid hormones

·        Treated with lithium carbonate, an anticonvulsant, or amiodarone

·        Pregnancy

·        Children under 2 years of age

Patient Preparation Instructions:  This test is unaffected by multivitamins (45 - 125 µg biotin) or biotin-only supplements.

For additional information see: 

Collection Devices:
Specimen Required:


Plasma: 2.0 mL

Specimen Stability 

Refrigerated: 7 days 

Frozen: 1 month, freeze only once 

Referral:

Shipping & Storage: Samples must be transferred to an aliquot tube and stored/shipped

·        Refrigerated if off-site testing to be performed within 48 hours of collection

·        Frozen if testing to be performed after 48 hours 

See #110-10-05 Serum / Plasma Separation Procedure & Transport

Requisition:
Reference Values:
Reference Intervals:
AgeFT4, pmol/L
<8 days20.8 - 54.4
8 days - < 5 weeks9.6 - 24.0 
5 weeks - <1 year8.0 - 18.2
1 – 5 years8.0 - 21.6
6 - 10 years10.4 - 21.6 
11 - 20 years8.0 - 20.8
³ 21 years9.7 - 25.7


Reference Intervals during Pregnancy (not on patient reports)

TrimesterFT4, pmol/L
1st trimester12.1 - 19.6
2nd trimester9.6 - 17.0
3rd trimester8.4 - 15.6


Method of Analysis:Roche Electrochemiluminescence

Availability:
Daily
See Also:
More Information: