Laboratory: Clinical Immunology
Test Name:
SmRNP - (S)
Test Code: RNP
Clinical Information:

Test performed at St. Boniface  Hospital Immunology Lab. SmRNP includes detection of antibodies against the combined SmRNP antigen configuration (Sm + RNP + RNP-A: U1 RNP-C protein C-terminal region motif of proteins A, C, and B/B1, U1RNA, snRNP particles U2,U4/U6, U5).  A positive result can be found in patients with SLE, MCTD, or Sjogrens’ Syndrome.

Collection Devices:
Specimen Required:
Blood: 5.0 mL

Serum: 1.0 mL
Serum: 1.0 mL

Separate serum; store and ship serum aliquot refrigerated.  Do NOT freeze.

Reference Values:

Negative = 0 - 0.9 AI


A negative result does not necessarily exclude autoimmune disease.  Positive results should not be interpreted in isolation and must be correlated with relevant clinical findings.
Within 1 Week
See Also:
More Information:

This antibody specificity is included in ANA Screen test and ENA test.